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News : 2ème Séminaire Nano/Microélectronique et Vivant - 18/12/2017
2ème Séminaire Nano/Microélectronique et Vivant - 18/12/2017
14h : Reetu Raj Pandey, Research Fellow, LIRMM, UMR5506 CNRS Université de Montpellier
Fabrication of electrochemical glucose biosensor based on carbon nanotube eld sect transistor
Abstract: Electrochemical biosensor is a class of sensor where the semiconducting, ionic or conducting material is directly in contact with biochemical analyte. This type of sensors transduces the biological signals into electrical signal. The device sensitivity and signal strength of such a sensor depends on analyze concentration, its composition and binding with electro conducting channel. One of the promising candidate material for such electrochemical biosensor are carbon nanotubes (CNTs) with exotic properties of signal detection.
14h45 : May C. Morris, Directeur de recherche CNRS, Institut des Biomolecules Max Mousseron, CNRS-UMR5247, Montpellier, France
Fluorescent Peptide Biosensors for probing kinase activities – new tools for cancer diagnostics and drug discovery
Abstract: One of the challenges of modern biology and nanomedicine consists in attempting to visualize biomolecules in their natural environment, in real-time and in a non-invasive fashion, so as to gain insight into their behaviour in both physiological and pathological settings. To this aim, we have developed a toolbox of uorescent biosensors through conjugation of environmentally-sensitive probes to synthetic modular polypeptides, which serve as reporters of protein kinases activities in human cancers. In particular, we have engineered a CDK4/Cyclin D-specic biosensor which has been implemented to monitor kinase hyperactivity in melanoma cell extracts, xenografts and skin biopsies, and a CDK5/p25-specic biosensor which reports on the dynamic activation of this kinase in glioblastoma cells.. More recently, we have developed lanthanide-based and carbon nanotube-peptide hybrid nanobiosensors which penetrate readily into living cells and respond to kinase hyperactivation or to its therapeutic inhibition in a robust and sensitive and fashion. Taken together, these optical biosensors constitute attractive tools for cancer diagnostics and drug discovery programmes.
16h15 : Nicole JAFFREZIC-RENAULT, Directeur de Recherche Emérite au CNRS, Institut des Sciences Analytiques, UMR 5280 CNRS-UCBL-ENS, Université de Lyon
Concepts de biocapteurs électrochimiques
Abstract: Le séminaire s’articulera autour de la relation cible-réaction biochimique-transduction.
Diérents exemples seront développés :
- BioFET enzymatiques
- Microconductimètres enzymatiques et eet de nanomatériaux
- Biocapteurs d’anité impédancemétriques
Lundi 18 décembre 2017, Montpellier, France
Salle de Séminaire, Bat 4
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